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Lotrisone: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: clotrimazole and betamethasone
  • Brand Name: Lotrisone

side effects drug center lotrisone (clotrimazole and betamethasone) drug - patient side effects and images

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

Lotrisone Patient Information Including Side Effects

Brand Names: Lotrisone

Generic Name: betamethasone and clotrimazole topical

What is betamethasone and clotrimazole topical (Lotrisone)?

Betamethasone is highly potent steroid that reduces itching, swelling, and redness of the skin.

Clotrimazole is an antifungal medication that fights infections caused by fungus.

Betamethasone and clotrimazole topical (for the skin) is a combination medicine used to treat fungal skin infections such as athlete's foot, jock itch, and ringworm.

Betamethasone and clotrimazole topical may also be used for purposes not listed in this medication guide.

What are the possible side effects of betamethasone and clotrimazole topical (Lotrisone)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • numbness, tingling, or stinging;
  • skin dryness or rash;
  • swelling; or
  • new infections.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about betamethasone and clotrimazole topical (Lotrisone)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Lotrisone Patient Information including How Should I Take

What should I discuss with my healthcare provider before using betamethasone and clotrimazole topical (Lotrisone)?

You may not be able to use this medicine if you are allergic to betamethasone or clotrimazole, or if you have ever had an allergic reaction to:

Tell your doctor if you have ever had:

  • a skin reaction to any steroid medicine;