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Differin Gel .1 Side Effects Center: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: adapalene gel
  • Brand Name: Differin Gel .1%

Differin Gel .1%(Adapalene Gel) side effects drug center

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

 

Differin Gel .1 Side Effects Center

What Is Differin?

Differin (adapalene) Gel, 0.1% is a retinoid used to treat acne. Differin Gel is available in generic form. Common side effects of Differin Gel include a brief sensation of warmth, stinging, tingling, or irritation immediately after applying the medication. Skin redness, dryness, itching, scaling, mild burning, or worsening of acne may occur during the first 2-4 weeks of using Differin Gel.

What Are Side Effects of Differin?

Side effects of Differin Gel usually decrease with continued use. Tell your doctor if you experience unlikely but serious side effects of Differin Gel including:

  • very red or irritated skin,
  • an intense burning sensation,
  • eye redness and watering (conjunctivitis),