Alkindi Sprinkle Side Effects Center
- Generic Name: hydrocortisone oral granules
- Brand Name: Alkindi Sprinkle
Alkindi Sprinkle (Hydrocortisone Oral Granules) side effects drug center
Alkindi Sprinkle Side Effects Center
What Is Alkindi Sprinkle?
Alkindi Sprinkle (hydrocortisone) is a corticosteroid indicated as replacement therapy in pediatric patients with adrenocortical insufficiency.
What Are Side Effects of Alkindi Sprinkle?
Side effects of Alkindi Sprinkle include:
- fluid retention,
- alteration in glucose tolerance,
- elevation in blood pressure,
- behavioral and mood changes,
Dosage for Alkindi Sprinkle
The recommended starting replacement dosage of Alkindi Sprinkle is 8 to 10 mg/m2 daily. Higher doses may be needed based on patient's age and symptoms of the disease. Use of lower starting doses may be sufficient in patients with residual but decreased endogenous cortisol production.
Alkindi Sprinkle In Children
The safety and effectiveness of Alkindi Sprinkle have been established in pediatric patients for replacement therapy of adrenocortical insufficiency. Alkindi Sprinkle are oral granules contained within capsules that must be opened and not swallowed whole to administer the granules. Additionally, Alkindi Sprinkle granules should not be administered via nasogastric or gastric tubes as they may cause tube blockage.
What Drugs, Substances, or Supplements Interact with Alkindi Sprinkle?
Alkindi Sprinkle may interact with other medicines such as:
- CYP3A4 inhibitors (such as anti-fungals: itraconazole, posaconazole, voriconazole; antibiotics: erythromycin and clarithromycin; antiretrovirals: ritonavir; grapefruit juice),
- CYP3A4 inducers (such as anticonvulsants: phenytoin, carbamazepine and oxcarbazepine; antibiotics: rifampicin and rifabutin; barbiturates: phenobarbital and primidone; antiretrovirals: efavirenz and nevirapine),
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