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Zetran: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Zetran - General Information

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)

 

Pharmacology of Zetran

Zetran, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Zetran, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Zetran was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.

 

Zetran for patients

This medicine is used to treat anxiety. This medicine is used to calm you.
It may be prescribed for patients who have trouble sleeping, Take this
medicine exactly as directed. It may be taken with food or milk if stomach
upset occurs, this medicine may cause drowsiness, possible drug interactions
may occur with other sedating medications or pain medications. Talk to your
doctor if you are taking any medications for depression, pain, or seizures.
Other sedative medications including over-the-counter antihistimines can
increase the side effects of this medicine and should be used cautiously.

 

Zetran Interactions

No information provided.

 

Zetran Contraindications

Valium Injection is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

 

Additional information about Zetran

Zetran Indication: Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. Mechanism Of Action: Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Drug Interactions: Amprenavir Amprenavir increases the effect and toxicity of benzodiazepineCimetidine Cimetidine increases the effect of the benzodiazepineClarithromycin The macrolide increases the effect of the benzodiazepineClozapine Increased risk of toxicityDigoxin The benzodiazepine increases the effect of digoxinErythromycin The macrolide increases the effect of the benzodiazepineEthotoin Possible increased levels of the hydantoin, decrease of benzodiazepineFluconazole Fluconazole increases the effect of the benzodiazepineFosamprenavir Amprenavir increases the effect and toxicity of benzodiazepineFosphenytoin Possible increased levels of the hydantoin, decrease of benzodiazepineIndinavir The protease inhibitor increases the effect of the benzodiazepineItraconazole The imidazole increases the effect of the benzodiazepineJosamycin The macrolide increases the effect of the benzodiazepineKava Kava increases the effect of the benzodiazepineKetoconazole The imidazole increases the effect of the benzodiazepineMephenytoin Possible increased levels of the hydantoin, decrease of benzodiazepineNelfinavir The protease inhibitor increases the effect of the benzodiazepineOmeprazole Omeprazole increases the effect of benzodiazepinePhenytoin Possible increased levels of the hydantoin, decrease of benzodiazepineQuinupristin This combination presents an increased risk of toxicityRifampin Rifampin decreases the effect of benzodiazepineRitonavir The protease inhibitor increases the effect of the benzodiazepineSaquinavir The protease inhibitor increases the effect of the benzodiazepineSt. John's Wort St. John's Wort could reduce the benzodiazepine effectVoriconazole The imidazole increases the effect of the benzodiazepine Food Interactions: Avoid alcohol.Take with food.Avoid excessive quantities of coffee or tea (caffeine).Avoid taking with grapefruit or grapefruit juice as grapefruit can significantly increase serum levels of this product. Generic Name: Diazepam Synonyms: DAP; Methyldiazepinone Drug Category: Adjuvants, Anesthesia; Anesthetics, Intravenous; Anti-anxiety Agents; Anticonvulsants; Antiemetics; GABA Modulators; Hypnotics and Sedatives; Muscle Relaxants, Central Drug Type: Small Molecule; Illicit; Approved Other Brand Names containing Diazepam: Alboral; Aliseum; Alupram; Amiprol; An-Ding; Ansiolin; Ansiolisina; Apaurin; Apo-Diazepam; Apozepam; Armonil; Assival; Atensine; Atilen; Bensedin; Bialzepam; Calmocitene; Calmpose; Cercine; Ceregulart; Condition; Diacepan; Dialag; Dialar; Diapam; Diastat; Diazemuls; Diazemulus; Diazepam Intensol; Diazepan; Diazetard; Dienpax; Dipam; Dipezona; Dizac; Domalium; Duksen; Duxen; E-Pam; Eridan; Eurosan; Evacalm; Faustan; Faustan,; Freudal; Frustan; Gewacalm; Gihitan; Kabivitrum; Kiatrium; LA III; La-Iii; Lamra; Lembrol; Levium; Liberetas; Mandrozep; Morosan; Neurolytril; Noan; Novazam; Novo-Dipam; Paceum; Pacitran; Paranten; Paxate; Paxel; Plidan; Pms-Diazepam; Pro-Pam; Q-Pam; Q-Pam Relanium; Quetinil; Quiatril; Quievita; Relaminal; Relanium; Renborin; Ruhsitus; Saromet; Sedapam; Sedipam; Seduksen; Seduxen; Serenack; Serenamin; Serenzin; Servizepam; Setonil; Sibazon; Sibazone; Solis; Sonacon; Stesolid; Stesolin; Tensopam; Tranimul; Tranqdyn; Tranquase; Tranquirit; Tranquo-Puren; Tranquo-Tablinen; Umbrium; Unisedil; Usempax Ap; Valaxona; Valeo; Valiquid; Valitran; Valium; Valrelease; Vatran; Velium; Vival; Vivol; Zetran; Zipan; Absorption: Essentially complete, with a bioavailability of 93%. Toxicity (Overdose): Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored. Protein Binding: 98.5% Biotransformation: Hepatic via the Cytochrome P450 enzyme system. The main active metabolite is desmethyldiazepam, in addition to minor active metabolites including temazepam and oxazepam. Half Life: Biphasic 1-2 days and 2-5 days, active metabolites with long half lives. Dosage Forms of Zetran: Emulsion IntramuscularTablet OralGel RectalSolution OralSolution Intramuscular Chemical IUPAC Name: 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Chemical Formula: C16H13ClN2O Diazepam on Wikipedia: https://en.wikipedia.org/wiki/Diazepam Organisms Affected: Humans and other mammals