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Viofuragyn: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Viofuragyn - General Information

A nitrofuran derivative with antiprotozoal and antibacterial activity. Viofuragyn acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)

 

Pharmacology of Viofuragyn

Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E. coli, staphylococci, Salmonella, Shigella, Proteus, Aerobacter aerogenes, Vibrio cholerae and Giardia lamblia. Its bactericidal activity is based upon its interference with DNA replication and protein production; this antimicrobial action minimizes the development of resistant organisms.

 

Viofuragyn for patients

 

Viofuragyn Interactions

 

Viofuragyn Contraindications

The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors.

 

Additional information about Viofuragyn

Viofuragyn Indication

For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.

Mechanism Of Action
Viofuragyn and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.
Generic Name
Furazolidone
Synonyms
Nitrofurazolidone; Nitrofurazolidonum; USAF EA-1
Drug Category
Anti-Infective Agents, Local; Anti-Infective Agents, Urinary; Antitrichomonal Agents; Monoamine Oxidase Inhibitors
Drug Type
Small Molecule; Approved
Other Brand Names containing Furazolidone
Bifuron; Corizium; Coryzium; Diafuron; Enterotoxon; Fiurox aerosol powder; Furall; Furaxon; Furaxone; Furazol; Furazolidine; Furazolidon; Furazon; Furidon; Furovag; Furox; Furoxal; Furoxane; Furoxon; Furoxone; Furoxone Liquid; Furoxone Swine Mix; Furozolidine; Giardil; Giarlam; Medaron; Neftin; Nicolen; Nifulidone; Nifuran; Nifurazolidone; Nitrofuroxon; Optazol; Ortazol; Puradin; Roptazol; Sclaventerol; Tikofuran; Topazone; Trichofuron; Tricofuron; Tricoron; Trifurox; Viofuragyn;
Absorption
Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration
Toxicity (Overdose)
Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors.
Biotransformation
Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Two major metabolites are produced: 3-amino-2-oxazolidone (AOZ) or beta-hydroxyethylhydrazine (HEH). AOZ is responsible for monoamine oxidase inhibition. Detoxification and elimination of the drug is done primarily by conjugation with glutathione.
Half Life
10 minutes
Dosage Forms of Viofuragyn
Tablet Oral
Chemical IUPAC Name
3-[(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
Chemical Formula
C8H7N3O5
Organisms Affected
Microbes (bacteria, parasites)