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Vestra: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Vestra - General Information

Vestra is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Vestra has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.

 

Pharmacology of Vestra

Vestra is a selective noradrenaline reuptake inhibitor (NaRI), the first
drug of new antidepressant class. Vestra is an a-ariloxybenzyl derivative of
morpholine. Vestra is primarily used to treat depression but has also been
found useful in the treatment of narcolepsy and panic disorders.

 

Vestra for patients

 

Vestra Interactions

Combined usage of MAO inhibitors should be avoided

 

Vestra Contraindications

Caution is recommended in patients with evidence of urinary retention and glaucoma

 

Additional information about Vestra

Vestra Indication: For the treatment of clinical depression. Mechanism Of Action: Vestra is a selective inhibitor of noradrenaline reuptake. It inhibitsnoradrenaline reuptake in vitro to a similar extent to the tricyclicantidepressant desmethylimipramine. Vestra does not affect dopamine orserotonin reuptake and it has low in vivo and in vitro affinityfor adrenergic, cholinergic, histaminergic, dopaminergic and serotonergicreceptors. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Reboxetine Synonyms: Reboxetine mesylate Drug Category: Antidepressive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Reboxetine: Edronax; Norebox; Vestra; Prolift; Solvex; Davedax; Absorption: Reboxetine is rapidly and extensively absorbed following oral administration. Toxicity (Overdose): Reports of seizures (rare) have been reported Protein Binding: 98% Biotransformation: Reboxetine is metabolized by dealkylation, hydroxylation and oxidation followedby glucuronide or sulphate conjugation. It is metabolized by the cytochrome P450CYP isoenzyme 3A4. Half Life: 12.5 hours Dosage Forms of Vestra: Tablet Oral Chemical IUPAC Name: (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine Chemical Formula: C19H23NO3 Reboxetine on Wikipedia: https://en.wikipedia.org/wiki/Reboxetine Organisms Affected: Humans and other mammals