Veldona (Amarillo Biosciences): Full Drug Profile

Veldona (Amarillo Biosciences) - General Information

Interferon alpha, 165 amino acids.

Pharmacology of Veldona (Amarillo Biosciences)

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Additional information about Veldona (Amarillo Biosciences)

Veldona (Amarillo Biosciences) Indication

For the treatment of oral warts arising from HIV infection

Mechanism Of Action

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.

Generic Name

Oral interferon alfa

Synonyms

Interferon alpha-2 precursor; Interferon alpha-A; LeIF A

Drug Category

Antiinfective; Antineoplastic

Drug Type

Biotech; Approved

Other Brand Names containing Oral interferon alfa

Veldona (Amarillo Biosciences);

Chemical IUPAC Name

Human interferon alpha

Chemical Formula

C860H1353N227O255S9

Organisms Affected

Humans and other mammals