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Tobramitsetin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Tobramitsetin - General Information

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]

 

Pharmacology of Tobramitsetin

Tobramitsetin, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections.

 

Tobramitsetin for patients

Patient Information:

TOBI is in a class of antibiotics that have caused hearing loss, dizziness, kidney damage, and harm to a fetus.
Ringing in the ears and hoarseness were two symptoms that were seen in more patients taking TOBI than placebo
in research studies. Patients with cystic fibrosis can have many symptoms. Some of these symptoms may be related
to your medications. If you have new or worsening symptoms, you should tell your doctor.

Hearing: You should tell your doctor if you have ringing in the ears, dizziness, or any changes in hearing.

Kidney Damage: Inform your doctor if you have any history of kidney problems.

Pregnancy: If you want to become pregnant or are pregnant while on TOBI, you should talk with your doctor about
the possibility of TOBI causing any harm.

Nursing Mothers: If you are nursing a baby, you should talk with your doctor before using TOBI.

 

Tobramitsetin Interactions

In clinical studies of TOBI, patients taking TOBI concomitantly with dornase alfa (PULMOZYME®, Genentech), (beta)-agonists, inhaled corticosteroids, other anti-pseudomonal antibiotics, or parenteral aminoglycosides demonstrated adverse experience profiles similar to the study population as a whole.

Concurrent and/or sequential use of TOBI with other drugs with neurotoxic or ototoxic potential should be avoided. Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. TOBI should not be administered concomitantly with ethacrynic acid, furosemide, urea, or mannitol.

 

Tobramitsetin Contraindications

TOBI is contraindicated in patients with a known hypersensitivity to any aminoglycoside.

 

Additional information about Tobramitsetin

Tobramitsetin Indication: For the treatment of pseudomonas aeruginosa lung infections Mechanism Of Action: Tobramitsetin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramitsetin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Tobramycin Synonyms: 3'-Deoxykanamycin B; Tobramycin Sulfate Drug Category: Anti-Bacterial Agents; Aminoglycosides Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Tobramycin: Aktob; Distobram; Gernebcin; NF 6; Nebcin; Nebramycin; Nebramycin 6; Nebramycin Factir 6; Nebramycin Factor 6; Nebramycin Vi; Obracin; Obramycin; Tenebrimycin; Tenemycin; Tobi; Tobracin; Tobradex; Tobradistin; Tobramaxin; Tobramitsetin; Tobramycetin; Tobrasone; Tobrex; Absorption: Not Available Toxicity (Overdose): LD50=441mg/kg (s.c. in mice) Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Tobramitsetin: Liquid IntravenousPowder, for solution IntravenousOintment OphthalmicSolution OphthalmicSolution Respiratory (inhalation)Liquid Ophthalmic Chemical IUPAC Name: 4-amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol Chemical Formula: C18H37N5O9 Tobramycin on Wikipedia: https://en.wikipedia.org/wiki/Tobramycin Organisms Affected: Enteric bacteria and other eubacteria