Terfonyl: Full Drug Profile

Terfonyl - General Information

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]

Pharmacology of Terfonyl

Terfonyl is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Additional information about Terfonyl

Terfonyl Indication

For the treatment of rheumatic fever and meningococcal meningitis

Mechanism Of Action

Terfonyl is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Generic Name

Sulfadiazine

Synonyms

Sulfadiazin; Sulfadiazene; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidine; Sulfapyrimidin; Sulphadiazine; SDA

Drug Category

Antiprotozoals; Anti-Infectives

Drug Type

Small Molecule; Approved

Other Brand Names containing Sulfadiazine

Adiazin; Adiazine; Coco-Diazine; Cocodiazine; Codiazine; Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit; Diazyl; Eskadiazine; Honey Diazine; Lantrisul; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Metha-Meridiazine; Microsulfon; Neazine; Neotrizine; Palatrize; Pecta-Diazine; Piridisir; Pirimal; Pyrimal; Quadetts; Quadramoid; Sanodiazine; Spofadrizine; Sterazine; Sulfacombin; Sulfaloid; Sulfatryl; Sulfazine; Sulfolex; Sulfonamides Duplex; Sulfonsol; Sulfose; Terfonyl; Theradiazine; Tri-Sulfameth; Trifonamide; Triple Sulfa; Triple Sulfas; Triple Sulfoid; Trisem; Truozine; Sulfa-Triple;

Toxicity (Overdose)

Oral LD₅₀ in mouse is 1500 mg/kg.

Chemical IUPAC Name

4-amino-N-pyrimidin-2-ylbenzenesulfonamide

Chemical Formula

C10H10N4O2S

Sulfadiazine on Wikipedia

https://en.wikipedia.org/wiki/Sulfadiazine

Organisms Affected

Enteric bacteria and other eubacteria