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Siplarol: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Siplarol - General Information

Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist.

 

Pharmacology of Siplarol

Siplarol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood.

 

Siplarol for patients

Patient Information:

Flupenthixol alone or with alcohol may cause blurred vision or drowsiness. Avoid driving, operating machinery, or performing other
activities that may become hazardous because of decreased alertness. Patients should be warned not to drink alcohol while taking
Flupenthixol.

Patients should discuss about the risks of taking Flupenthixol to the fetus and child with the doctors if they are breastfeeding,
pregnant or thinking about becoming pregnant.

Patients should be advised to use sunscreen and wear protective clothing to avoid sunburn, because flupenthixol can cause your skin to
be more sensitive to sunlight than it is normally.

 

Siplarol Interactions

Drug Interactions:

Flupenthixol may interact with some drugs, like:
- Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics
- Arecoline
- Eproxindine
- Ethanol: Flupenthixol and Ethanol cause additive CNS depression
- Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants

 

Siplarol Contraindications

Contraindications:

Flupenthixol should not be given to patients who are hypersensitive to the thioxanthenes. It
is also contraindicated in patients who have suspected or diagnosed subcortical brain damage,
blood dyscrasias, pheochromocytoma, liver damage, cerebrovascular or renal insufficiency,
severe cardiovascular disorders. Patients with confusion/agitation should not use Flupenthixol.

Women of childbearing potential or during lactation should discuss with the doctors about the
potential risk of Flupenthixol to the fetus and child.

 

Additional information about Siplarol

Siplarol Indication

For use in the treatment of schizophrenia and depression

Mechanism Of Action
Siplarol is a thioxanthene antipsychotic. The mechanism of action of Siplarol is not completely understood. Siplarol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.
Drug Interactions
Donepezil Possible antagonism of action
Food Interactions
Take with food to reduce irritation.
Generic Name
Flupenthixol
Synonyms
Flupenthixole
Drug Category
Antipsychotics; Thioxanthenes; Dopamine Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Flupenthixol
Depixol; Emergil; Fluanxol; Fluanxol Depot; Flupentixol; Flurentixol; Fluxanxol; Siplaril; Siplarol;
Absorption
Fairly slow and incomplete after oral administration
Toxicity (Overdose)
LD50=300 mk/kg (Oral in mice); LD50=791 mg/kg (Oral in rats); LD50=87 mk/kg (IV in mice); LD50=37 mg/kg (IV in rats)
Protein Binding
Highly bound to plasma proteins (>95%)
Biotransformation
Mainly hepatic
Half Life
19 to 39 hours
Chemical IUPAC Name
2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
Chemical Formula
C23H25F3N2OS
Organisms Affected
Humans and other mammals