Sanvar

Sanvar - General Information

Sanvar is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.

Pharmacology of Sanvar

Sanvar is a somatostatin analog with a higher metabolic stability than the parent hormone. Sanvar reduces splanchnic blood flow; inhibits growth hormone release, and inhibits the release of peptides and vasoactive compounds from neuroendocrine tumors.

Additional information about Sanvar

Sanvar Indication: For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
Mechanism Of Action: The exact mechanism of action is unknown, although one study has provided in vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect in the analgesic effects of vapreotide (PMID: 7556407).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Vapreotide
Synonyms: Vapreotide acetate; Vapreotida [INN-Spanish]; Vapreotidum [inn-latin]; RC-160
Drug Category: Analgesics; Antineoplastic Agents
Drug Type: Small Molecule; Approved; Investigational

Other Brand Names containing Vapreotide: Sanvar; Sanvar IR;
Absorption: Not Available
Toxicity (Overdose): Safety data are limited, however, headache, fatigue, diarrhea, nausea, vomiting, and abdominal pain have been reported commonly with the use of vapreotide.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 30 minutes
Dosage Forms of Sanvar: Not Available
Chemical IUPAC Name: 10-(4-aminobutyl)-N-[1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-19-[(2-amino-3-phenylpropanoyl)amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Chemical Formula: C57H70N12O9S2
Vapreotide on Wikipedia: Not Available
Organisms Affected: Humans and other mammals