Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Reise-Engletten: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Reise-Engletten - General Information

Reise-Engletten (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect.

 

Pharmacology of Reise-Engletten

Reise-Engletten is an antiemetics drug combination that contains diphenhydramine and theophylline. It is not effective in the treatment of nausea associated with cancer chemotherapy. Reise-Engletten directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo.

 

Reise-Engletten for patients

 

Reise-Engletten Interactions

Dimenhydrinate may decrease emetic response to apomorphine.

 

Reise-Engletten Contraindications

Dimenhydrinate may impede diagnosis of appendicitis and may obscure signs of overdose.

 

Additional information about Reise-Engletten

Reise-Engletten Indication

Used for treating vertigo, motion sickness, and nausea associated with pregnancy.

Mechanism Of Action
The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect.
Drug Interactions
Donepezil Possible antagonism of action
Food Interactions
Avoid alcohol.
Generic Name
Dimenhydrinate
Synonyms
Diphenhydramine Theoclate; Diphenhydrinate
Drug Category
Antiemetics; Histamine H1 Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Dimenhydrinate
Amosyt; Anautine; Andramine; Antemin; Aviomarin; Chloranautine; Diamarin; Dimate; Dimenest; Dimentabs; Dramalen; Dramamin; Dramarin; Dramilin; Dramyl; Dromyl; Eldodram; Gravinol; Gravol; Hydrinate; Menhydrinate; Neo-Navigan; Novamine; Permital; Reise-Engletten; Supremal; Teodramin; Travelin; Travelmin; Troversin; Vomex A; Xamamina;
Absorption
Well absorbed after oral administration.
Toxicity (Overdose)
Symptoms of overdose include delerium and hallucinations.
Protein Binding
98 to 99%.
Biotransformation
Hepatic (cytochrome P-450 system).
Half Life
1 to 4 hours
Dosage Forms of Reise-Engletten
Solution Intravenous
Chemical IUPAC Name
2-benzhydryloxyethyl-dimethylazanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate
Chemical Formula
C24H28ClN5O3
Organisms Affected
Humans and other mammals