Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Pirenzepin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Pirenzepin - General Information

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients. [PubChem]

 

Pharmacology of Pirenzepin

Pirenzepin belongs to a group of medications called antispasmodics/anticholinergics. These medications are used to relieve cramps or spasms of the stomach, intestines, and bladder. Pirenzepin is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

 

Pirenzepin for patients

Patient Information:

Check with your doctor before you take Pirenzepine. It may cause blurry vision and dizziness, which may affect driving, operating machinery and other
activities. It may also cause dryness of the mouth, nose and throat.
Do not change the dose or stop Pirenzepine without consulting your doctor. The dose of Pirenzepine needs to reduced gradually to prevent the
withdrawal side effects.

 

Pirenzepin Interactions

Drug Interactions:

Pirenzepine may interact with the following drugs, which may affect the effect of Pirenzepine or whose effects may be affected.
- Antacids
- Diarrhea medicine containing kaolin or attapulgite
- Ketoconazole
- Central nervous system (CNS) depressants
- Other anticholinergics
- Tricyclic antidepressants (e.g., Elavil, Asendin, Anafranil, Pertofrane, Sinequan, Tofranil, Aventyl, Surmontil)
- Potassium chloride (e.g., Kay Ciel)

 

Pirenzepin Contraindications

 

Additional information about Pirenzepin

Pirenzepin Indication: For the treatment of peptic ulcer, gastric ulcer, and duodenal ulcer. Mechanism Of Action: Pirenzepin is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Pirenzepine Synonyms: Not Available Drug Category: Anti-Ulcer Agents; Antimuscarinics; Antispasmodics Drug Type: Small Molecule; Approved Other Brand Names containing Pirenzepine: Bisvanil; Gasteril; Gastrozepin; Leblon; Pirenzepin; Pirenzepina [Inn-Spanish]; Pirenzepine Gastrozepin; Pirenzepinum [Inn-Latin]; Tabe; Ulcosan; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Pirenzepin: Not Available Chemical IUPAC Name: 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one Chemical Formula: C19H21N5O2 Pirenzepine on Wikipedia: https://en.wikipedia.org/wiki/Pirenzepine Organisms Affected: Humans and other mammals