Peptavlon
Peptavlon - General Information
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem]
Pharmacology of Peptavlon
Peptavlon is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.
Additional information about Peptavlon
Peptavlon Indication: Used as a diagnostic aid for evaluation of gastric acid secretory function
Mechanism Of Action: The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Peptavlon stimulates pancreatic secretion, especially when administered in large intramuscular doses. Peptavlon also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pentagastrin
Synonyms: Not Available
Drug Category: Diagnostic aid; gastric function
Drug Type: Small Molecule; Approved
Other Brand Names containing Pentagastrin: Peptavlon;
Absorption: Rapidly absorbed after parenteral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Primarily hepatic
Half Life: 10 minutes or less
Dosage Forms of Peptavlon: Not Available
Chemical IUPAC Name: (3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid
Chemical Formula: C37H49N7O9S
Pentagastrin on Wikipedia: https://en.wikipedia.org/wiki/Pentagastrin
Organisms Affected: Humans and other mammals