Optimine

Optimine - General Information

Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.

Pharmacology of Optimine

Optimine is an antihistamine, related to cyproheptadine, with anti-serotonin, anticholinergic (drying), and sedative effects. Optimine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, azatadine is not used clinically as an anti-psychotic. Antihistamines antagonize the vasodilator effect of endogenously released histamine, especially in small vessels, and mitigate the effect of histamine which results in increased capillary permeability and edema formation. As consequences of these actions, antihistamines antagonize the physiological manifestations of histamine release in the nose following antigen-antibody interaction, such as congestion related to vascular engorgement, mucosal edema, and profuse, watery secretion, and irritation and sneezing resulting from histamine action on afferent nerve terminals.

Optimine for patients

1. Products containing antihistamines may cause drowsiness.
2. Patients should not engage in activities requiring mental alertness, such as driving or operating machinery or appliances.
3. Alcohol or other sedative drugs may enhance the drowsiness caused by antihistamines.
4. Patients should not take TRINALIN REPETABS Tablets if they are receiving a monoamine oxidase inhibitor or within 2 weeks of stopping such treatment.
5. This medication should not be given to children less than 12 years of age.

Optimine Interactions

MAO inhibitors prolong and intensify the effects of antihistamines. Concomitant use of antihistamines with alcohol, tricyclic antidepressants, barbiturates, or other central nervous system depressants may have an additive effect.

When sympathomimetic drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive reactions, including hypertensive crises, may occur. The antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics. Beta-adrenergic blocking agents may also interact with sympathomimetics. Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis. Antacids increase the rate of absorption of pseudoephedrine, while kaolin decreases it.

Optimine Contraindications

Antihistamines should not be used to treat lower respiratory tract symptoms, including asthma. This product is contraindicated in patients with narrow-angle glaucoma or urinary retention, and in patients receiving monoamine oxidase (MAO) inhibitor therapy or within 2 weeks of stopping such treatment. It is also contraindicated in patients with severe hypertension, severe coronary artery disease, hyperthyroidism, and in those who have shown hypersensitivity or idiosyncrasy to its components, to adrenergic agents, or to other drugs of similar chemical structures. Manifestations of patient idiosyncrasy to adrenergic agents include: insomnia, dizziness, weakness, tremor, or arrhythmias.

Additional information about Optimine

Optimine Indication: For the relief of the symptoms of upper respiratory mucosal congestion in perennial and allergic rhinitis, and for the relief of nasal congestion and eustachian t.b. congestion.
Mechanism Of Action: Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Take with food to reduce irritation.
Avoid alcohol.
Generic Name: Azatadine
Synonyms: Azatadina [INN-Spanish]; Azatadine Maleate; Azatadinum [INN-Latin]; Azatidine
Drug Category: Histamine H1 Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Azatadine: Optimine;
Absorption: Well absorbed after oral administration.
Toxicity (Overdose): The oral LD₅₀ in mature rats and mice was greater than 1700 mg/kg and 600 mg/kg, respectively. Symptoms of overdose include clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Optimine: Tablet Oral
Chemical IUPAC Name: Not Available
Chemical Formula: C20H22N2
Azatadine on Wikipedia: https://en.wikipedia.org/wiki/Azatadine
Organisms Affected: Humans and other mammals