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Nu-Cloxi: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Nu-Cloxi - General Information

A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]

 

Pharmacology of Nu-Cloxi

Nu-Cloxi is a semisynthetic antibiotic in the same class as penicillin. Nu-Cloxi is for use against staphylococci that produce beta-lactamase.

 

Additional information about Nu-Cloxi

Nu-Cloxi Indication: Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci. Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor. Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexateAnisindione The IV penicillin increases the anticoagulant effectDicumarol The IV penicillin increases the anticoagulant effectAcenocoumarol The IV penicillin increases the anticoagulant effectWarfarin The IV penicillin increases the anticoagulant effectDemeclocycline Possible antagonism of actionDoxycycline Possible antagonism of actionEthinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptiveMestranol This anti-infectious agent could decrease the effect of the oral contraceptiveMethacycline Possible antagonism of actionMinocycline Possible antagonism of actionOxytetracycline Possible antagonism of actionRolitetracycline Possible antagonism of actionTetracycline Possible antagonism of action Food Interactions: Take on an empty stomach. Generic Name: Cloxacillin Synonyms: Cloxacillin Sodium Drug Category: Anti-Bacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Cloxacillin: Novo-Cloxin; Nu-Cloxi; Absorption: Well absorbed from the gastrointestinal tract. Toxicity (Overdose): Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat. Protein Binding: 95% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Nu-Cloxi: Powder, for solution IntramuscularPowder, for solution OralPowder, for solution IntravenousCapsule Oral Chemical IUPAC Name: (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical Formula: C19H18ClN3O5S Cloxacillin on Wikipedia: https://en.wikipedia.org/wiki/Cloxacillin Organisms Affected: Enteric bacteria and other eubacteria