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Methixart: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Methixart - General Information

Methixart (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]

 

Pharmacology of Methixart

Methixart is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Methixart has been discontinued.

 

Additional information about Methixart

Methixart Indication

Used for the symptomatic treatment of parkinsonism.

Mechanism Of Action
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.
Generic Name
Metixene
Synonyms
Methixen [German]; Methixene; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Metixeno [INN-Spanish]; Metixenum [INN-Latin]
Drug Category
Antiparkinson Agents; Muscarinic Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Metixene
Atosil; Contalyl; Methixart; Tremaril; Tremaril hydrochloride; Tremonil; Trest;
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Toxicity (Overdose)
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Biotransformation
Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Chemical IUPAC Name
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Chemical Formula
C20H23NS
Organisms Affected
Humans and other mammals