Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Mestinon-SR: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Mestinon-SR - General Information

A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. [PubChem]

 

Pharmacology of Mestinon-SR

Mestinon-SR is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and doesn't cross the blood-brain barrier. Mestinon-SR has a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.

 

Mestinon-SR for patients

 

Mestinon-SR Interactions

No Information Provided.

 

Mestinon-SR Contraindications

Mestinon is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.

 

Additional information about Mestinon-SR

Mestinon-SR Indication: For the treatment of myasthenia gravis. Mechanism Of Action: Mestinon-SR inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine. Drug Interactions: Betamethasone The corticosteroid decreases the effect of anticholinesterasesCorticotropin The corticosteroid decreases the effect of anticholinesterasesCortisone acetate The corticosteroid decreases the effect of anticholinesterasesCosyntropin The corticosteroid decreases the effect of anticholinesterasesDexamethasone The corticosteroid decreases the effect of anticholinesterasesFludrocortisone The corticosteroid decreases the effect of anticholinesterasesHydrocortisone The corticosteroid decreases the effect of anticholinesterasesMethylprednisolone The corticosteroid decreases the effect of anticholinesterasesParamethasone The corticosteroid decreases the effect of anticholinesterasesPrednisolone The corticosteroid decreases the effect of anticholinesterasesPrednisone The corticosteroid decreases the effect of anticholinesterasesSuccinylcholine The corticosteroid decreases the effect of anticholinesterasesTriamcinolone The corticosteroid decreases the effect of anticholinesterases Food Interactions: Not Available Generic Name: Pyridostigmine Synonyms: Pyridostigmine Bromide; Pyridostigmine Bromine; Pyridostigminum; Pyridine N-Oxide Drug Category: Antimyasthenics; Cholinesterase Inhibitors; Parasympathomimetics Drug Type: Small Molecule; Approved Other Brand Names containing Pyridostigmine: Mestinon; Regonol; Mestinon-SR; Absorption: Poorly absorbed from the GI tract with an oral bioavailability of 7.6 +/- 2.4%. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Hydrolysis by cholinesterases and by liver. Half Life: 3 hours following oral administration. Dosage Forms of Mestinon-SR: Tablet OralTablet, extended release Oral Chemical IUPAC Name: (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate Chemical Formula: C9H13N2O2+ Pyridostigmine on Wikipedia: https://en.wikipedia.org/wiki/Pyridostigmine Organisms Affected: Humans and other mammals