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Mentax-tc: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Mentax-tc - General Information

Mentax-tc hydrochloride is a synthetic benzylamine antifungal agent. Mentax-tc works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes.

 

Pharmacology of Mentax-tc

Mentax-tc is an antifungal agent that acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. It is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is active also against Candida albicans and this activity is superior to that of terbinafine and naftifine. Mentax-tc also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.

 

Mentax-tc for patients

  1. Use Mentax® Cream, 1%, as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Mentax® Cream, 1%, is for external use only.
  2. Dry the affected area(s) thoroughly before application, if you wish to apply Mentax® Cream, 1%, after bathing.
  3. Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after the end of the prescribed treatment period, or sooner, if the condition worsens.
  4. Inform the physician if the area of application shows signs of increased irritation, redness, itching, burning, blistering, swelling, or oozing.
  5. Avoid the use of occlusive dressings unless otherwise directed by the physician.
  6. Do not use this medication for any disorder other than that for which it was prescribed.

 

Mentax-tc Interactions

Potential drug interactions between Mentax® (butenafine HCl cream) Cream, 1%, and other drugs have not been systematically evaluated.

 

Mentax-tc Contraindications

Mentax® (butenafine HCl cream) Cream, 1%, is contraindicated in individuals who have known or suspected sensitivity to Mentax® Cream, 1%, or any of its components.

 

Additional information about Mentax-tc

Mentax-tc Indication

For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.

Mechanism Of Action
Like allylamines, butenafine inhibits ergosterol biosynthesis by blocking squalene epoxidation. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents.
Generic Name
Butenafine
Synonyms
Butenafina [INN-Spanish]; Butenafine HCL; Butenafine hydrochloride; Butenafine [INN]; Butenafinum [INN-Latin]
Drug Category
Antifungal Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Butenafine
Lotrimin Ultra; Mentax; Mentax-tc;
Absorption
The total amount absorbed through the skin into the systemic circulation has not been quantified.
Biotransformation
The primary metabolite in urine was formed through hydroxylation at the terminal t-butyl side-chain.
Half Life
Following topical application, a biphasic decline of plasma butenafine concentrations was observed with the half-lives estimated to be 35 hours initial and over 150 hours terminal.
Dosage Forms of Mentax-tc
Cream Topical
Chemical IUPAC Name
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
Chemical Formula
C23H27N
Organisms Affected
Fungi