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Lamoryl: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Lamoryl - General Information

An antifungal antibiotic. Lamoryl may be given by mouth in the treatment of tinea infections. [PubChem]

 

Pharmacology of Lamoryl

Lamoryl is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Lamoryl is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.

 

Lamoryl for patients

 

Lamoryl Interactions

Patients on warfarin-type anticoagulant therapy may require dosage adjustment of the anticoagulant during and after griseofulvin therapy. Concomitant use of barbiturates usually depresses griseofulvin activity and may necessitate raising the dosage.

The concomitant administration of griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthrough bleeding.

 

Lamoryl Contraindications

This drug is contraindicated in patients with porphyria, hepatocellular failure, and in individuals with a history of hypersensitivity to griseofulvin.

 

Additional information about Lamoryl

Lamoryl Indication

For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.

Mechanism Of Action
Lamoryl is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin.
Drug Interactions
Amobarbital The barbiturate decreases the effect of griseofulvin
Food Interactions
Take this medication with a high fat meal, fatty foods increase bioavailability.
Generic Name
Griseofulvin
Synonyms
Griseofulvina [INN-Spanish]; Griseofulvine [INN-French]; Griseofulvinum [INN-Latin]
Drug Category
Antibiotics, Antifungal; Antibacterial Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Griseofulvin
Amudane; Biogrisin-fp; Curling factor; Delmofulvina; Fulcin; Fulcine; Fulvican grisactin; Fulvicin; Fulvicin P/G; Fulvicin U/F; Fulvicin-P/G; Fulvicin-U/F; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin; Gresfeed; Gricin; Grifulin; Grifulvin; Grifulvin V; Gris-PEG; Grisactin; Grisactin Ultra; Griscofulvin; Grisefuline; Griseo; Griseofulvin forte; Griseofulvin-forte; Griseomix; Grisetin; Grisofulvin; Grisovin; Grisovin FP; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Likunden; Murfulvin; Neo-Fulcin; Neocid; Poncyl; Spirofulvin; Sporostatin; Sporostatin xan; Xuanjing;
Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Toxicity (Overdose)
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Biotransformation
Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
Half Life
9-21 hours
Dosage Forms of Lamoryl
Tablet Oral
Chemical IUPAC Name
(2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
Chemical Formula
C17H17ClO6
Organisms Affected
Yeast and other Trichophyton or Microsporum fungi