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GBZ: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

GBZ - General Information

An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem]

 

Pharmacology of GBZ

GBZ, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.

 

Additional information about GBZ

GBZ Indication: For management of High blood pressure Mechanism Of Action: GBZ's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Guanabenz Synonyms: Not Available Drug Category: Sympatholytics; Antihypertensive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Guanabenz: GBZ; Guanabenz Acetate; Guanabenz [USAN-INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy 8678 base; Wytensin; Absorption: Approximately 75% absorbed from gastrointestinal tract Toxicity (Overdose): Excessive contraction of the pupils, irritabilitylow blood pressure, sleepiness, slow heartbeat, sluggishness Protein Binding: 90% Biotransformation: Hepatic Half Life: 6 hours. Dosage Forms of GBZ: Not Available Chemical IUPAC Name: 2-[(2,6-dichlorophenyl)methylideneamino]guanidine Chemical Formula: C8H8Cl2N4 Guanabenz on Wikipedia: https://en.wikipedia.org/wiki/Guanabenz Organisms Affected: Humans and other mammals