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Eskazine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Eskazine - General Information

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]

 

Pharmacology of Eskazine

Eskazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Eskazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

 

Eskazine for patients

 

Eskazine Interactions

No information provided.

 

Eskazine Contraindications

A known hypersensitivity to phenothiazines, comatose or greatly depressed states due to central nervous system depressants and, in cases of existing blood dyscrasias, bone marrow depression and pre-existing liver damage.

 

Additional information about Eskazine

Eskazine Indication: For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. Mechanism Of Action: Eskazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Trifluoperazine Synonyms: Not Available Drug Category: Antipsychotics; Antiemetics; Phenothiazines Drug Type: Small Molecule; Approved Other Brand Names containing Trifluoperazine: Apo-Trifluoperazine; Eskazine; Eskazinyl; Fluoperazine; Jatroneural; Modalina; Novo-Trifluzine; PMS Trifluoperazine; Stelazine; Stelazine Concentrate; Stellazine; Synklor; Terfluzine; Trazine; Trifluoperazin; Trifluoperazina; Trifluoperazine Dihydrochloride; Trifluoperazine HCl; Trifluoperazine Hydrochloride; Trifluoromethylperazine; Trifluoroperazine; Trifluoroperazine Dihydrochloride; Trifluoroperazine Hydrochloride; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; Triphthazine; Triphthazine Dihydrochloride; Tryptazine; Tryptazine Dihydrochloride; Absorption: Not Available Toxicity (Overdose): Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Eskazine: Tablet OralSyrup Oral Chemical IUPAC Name: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine Chemical Formula: C21H24F3N3S Trifluoperazine on Wikipedia: https://en.wikipedia.org/wiki/Trifluoperazine Organisms Affected: Humans and other mammals