Elmedal: Full Drug Profile

Elmedal - General Information

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter&

Pharmacology of Elmedal

Elmedal is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Additional information about Elmedal

Elmedal Indication

For the treatment of backache and ankylosing spondylitis

Mechanism Of Action

Elmedal binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Generic Name

Phenylbutazone

Drug Category

Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs)

Drug Type

Small Molecule; Approved

Other Brand Names containing Phenylbutazone

'Esteve'; Alindor; Alka Butazolidin; Alkabutazona; Alqoverin; Ambene; Anerval; Anpuzone; Antadol; Anuspiramin; Apo-Phenylbutazone; Arthrizon; Artizin; Artrizin; Artrizone; Artropan; Azdid; Azobutyl; Azolid; B.T.Z.; Benzone; Betazed; Bizolin; Bizolin 200; Bunetzone; Busone; Buta Phen; Butacompren; Butacote; Butadion; Butadiona; Butadione; Butagesic; Butalgina; Butalidon; Butaluy; Butapirazol; Butapirazole; Butapyrazole; Butarecbon; Butartril; Butartrina; Butatron; Butazina; Butazolidin; Butazolidine; Butazona; Butazone; Bute; Butidiona; Butiwas-Simple; Butone; Butoz; Butylpyrin; Buvetzone; Buzon; Chembutazone; Cotylbutazone; Digibutina; Diossidone; Diozol; Diphebuzol; Diphenylbutazone; Ecobutazone; Elmedal; Equi Bute; Equipalazone; Eributazone; Exrheudon N; Febuzina; Fenartil; Fenibutal; Fenibutasan; Fenibutazona; Fenibutol; Fenilbutazona; Fenilbutina; Fenilbutine; Fenilidina; Fenotone; Fenylbutazon; Ia-But; Intalbut; Intrabutazone; Intrazone; Ipsoflame; Kadol; Lingel; Malgesic; Mepha-Butazon; Mephabutazon; Mephabutazone; Merizone; Nadazone; Nadozone; Neo-Zoline; Novophenyl; Phebuzin; Phebuzine; Phenbutazol; Phenbutazone; Phenopyrine; Phenyl-Mobuzon; Phenylbutaz; Phenylbutazonum; Phenyzene; Phenyzone; Pirarreumol "B"; Pirarreumol B; Praecirheumin; Pyrabutol; Pyrazolidin; Rectofasa; Reudo; Reudox; Reumasyl; Reumazin; Reumazol; Reumune; Reumuzol; Reupolar; Robizon-V; Robizone; Robizone-V; Rubatone; Scanbutazone; Schemergin; Shigrodin; Tazone; Tencodyne; Tetnor; Tevcodyne; Therazone; Ticinil; Todalgil; Usaf Ge-15; Uzone; VAC-10; Wescozone; Zolaphen; Zolidinum;

Toxicity (Overdose)

Oral, LD₅₀ = 238 mg/kg (mouse); Oral, LD₅₀ = 781 mg/kg (rabbit); Oral, LD₅₀ = 245 mg/kg (rat); Oral, LD₅₀ = 375 mg/kg (rat)

Dosage Forms of Elmedal

Tablet Oral

Chemical IUPAC Name

4-butyl-1,2-di(phenyl)pyrazolidine-3,5-dione

Chemical Formula

C19H20N2O2

Phenylbutazone on Wikipedia

https://en.wikipedia.org/wiki/Phenylbutazone

Organisms Affected

Humans and other mammals