Echodide
Echodide - General Information
A potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. [PubChem]
Pharmacology of Echodide
Echodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
Echodide for patients
Echodide Interactions
Phospholine Iodide potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides. Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive effects of Phospholine Iodide.
Echodide Contraindications
- Active uveal inflammation.
- Most cases of angle-closure glaucoma, due to the possibility of increasing angle block.
- Hypersensitivity to the active or inactive ingredients.
Additional information about Echodide
Echodide Indication: For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Mechanism Of Action: Echodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. It thereby causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.
Drug Interactions: Succinylcholine The agent increases the effect of succinylcholine
Food Interactions: Not Available
Generic Name: Echothiophate Iodide
Synonyms: Not Available
Drug Category: Cholinesterase Inhibitors; Miotics; Parasympathomimetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Echothiophate Iodide: Echodide;
Absorption: Not Available
Toxicity (Overdose): Side effects include blurred vision or change in near or distant vision and eye pain.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Echodide: Solution / drops Ophthalmic
Chemical IUPAC Name: 2-diethoxyphosphorylsulfanylethyl-trimethylazanium iodide
Chemical Formula: C9H23INO3PS
Echothiophate Iodide on Wikipedia: https://en.wikipedia.org/wiki/Echothiophate
Organisms Affected: Humans and other mammals