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lixisenatide/insulin glargine (LixiLan): Dosing and Uses

 

Classes: Antidiabetics, Glucagon-like Peptide-1 Agonists; Antidiabetics, Long-Acting Insulins

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dosing and uses of LixiLan (lixisenatide/insulin glargine)

 

Type 2 Diabetes Mellitus

Pending FDA approvaL

Fixed ratio combination of insulin glargine 100 units/mL and lixisenatide, a once-daily prandial GLP-1 receptor agonist for type 2 Dm

 

Pediatric dosage forms and strengths

Safety and efficacy not established

 

Pharmacology of LixiLan (lixisenatide/insulin glargine)

Mechanism of action

Lixisenatide: Incretin mimetic; analogue of human glucagonlike peptide-1 (GLP-1); acts as GLP-1 receptor agonist to augment glucose-dependent insulin secretion

Insulin glargine: Insulin and its analogues lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production; insulin inhibits lipolysis and proteolysis and enhances protein synthesis; targets include skeletal muscle, liver, and adipose tissue