potassium chloride (KDur, Slow K, Kaon Cl 10, KCl, K10, Klor-Con M, Klor Con M10, Klor Con M15, Klor Con M20, KlorCon, Klotrix, KTab, MicroK, K8)
Dosing and uses of Stelara (ustekinumab)
Adult dosage forms and strengths
tablet
- 20mEq
tablet, extended-release
- 8mEq
- 10mEq
- 15mEq
- 20mEq
capsules, extended-release
- 8mEq
- 10mEq
injectable solution
- 1mEq/mL
- 1.5mEq/mL
- 2mEq/mL
- 3mEq/mL
- 4mEq/mL
premix IV in plastic container
- 10mEq
- 20mEq
- 30mEq
- 40mEq
Hypokalemia
20-40 mEq PO BID-QId
Hypokalemia Prophylaxis
Start: 20 mEq PO qDay
Dosing considerations
- Dosing varies; adjust to serum potassium levels
Pediatric dosage forms and strengths
tablet
- 20mEq
tablet, extended-release
- 8mEq
- 10mEq
- 15mEq
- 20mEq
capsules, extended-release
- 8mEq
- 10mEq
injectable solution
- 1mEq/mL
- 1.5mEq/mL
- 2mEq/mL
- 3mEq/mL
- 4mEq/mL
premixed IV in plastic container
- 10mEq
- 20mEq
- 30mEq
- 40mEq
Hypokalemia
0.5-2 mEq/kg PO q12hr
Monitor closely: 0.5 mEq/kg/hr IV for 1-2 hr
Stelara (ustekinumab) adverse (side) effects
Frequency not defined
Arrhythmias
Bleeding
Diarrhea
Dyspepsia
Hyperkalemia
Nausea
Rash
Vomiting
Warnings
Contraindications
Hypersensitivity
Untreated Addison disease
Hyperkalemia
Renal failure
Cautions
CV disease
Impaired renal fxn
Pregnancy and lactation
Pregnancy category: C
Lactation: N/A
Pregnancy categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology of Stelara (ustekinumab)
Mechanism of action
Essential in physiologic processes
Elimination
Excretion: Urine
Administration
IV Incompatibilities
Additive: Ampho B
Y-site: Diazepam
IV Compatibilities
Additive: Aminophylline, amiodarone, Ca gluconate, cimetidine, clindamycin, dobutamine, dopamine, erythromycin, furosemide, heparin, hydrocortisone, lidocaine, norepinephrine, Na bicarb, vancomycin, verapamiL
Y-site: Amiodarone, aminophylline, ampicillin, atropine, Ca gluconate, dobutamine, dopamine, epinephrine, esmolol, fentanyl, furosemide, heparin, lidocaine, morphine, norepinephrine, Na bicarB
Not spec.: Cefazolin, tetracycline
