scopolamine ophthalmic (Isopto Hyoscine)

Dosing and uses of Isopto Hyoscine (scopolamine ophthalmic)

• Adult
• Pediatric

 

Adult dosage forms and strengths

ophthalmic solution

• 0.25%

 

Iridocyclitis

Discontinued by manufacturer (12/18/2012)

Indicated preoperatively and/or postoperatively for iridocyclitis

Instill 1-2 gtt into eye(s) up to 4 times/day

 

Mydriasis & Cycloplegia

Indicated in diagnostic procedures

Instill 1-2 gtt into eye(s) 1 hr before refracting

 

Administration

Avoid excessive absorption by compressing lacrimal sac with fingers for 2-3 minutes after instillation

 

Pediatric dosage forms and strengths

Safety and efficacy not established

 

Isopto Hyoscine (scopolamine ophthalmic) adverse (side) effects

Frequency not defined

Local irritation

Eczematoid dermatitis

Excessive use may cause systemic effects (eg, somnolence, drowsiness, visual hallucinations)

Xerostomia

Exudate

Photophobia

Vascular congestion

Blurred vision

Edema

Follicular conjunctivitis

Increased intraocular pressure

 

Warnings

Contraindications

Hypersensitivity

Primary glaucoma or narrow anterior chamber angle

 

Cautions

Do not touch dropper to avoid contamination; contaminated multi-dose solutions may cause bacterial keratitis

Estimate depth anterior chamber angle to avoid inducing angle-closure glaucoma

Initial visual disturbances and pain within the eye are reasons for discontinuation

Ophthalmic use only

Remove contact lenses prior to administration and wait 15 min before reinserting

 

Pregnancy and lactation

Pregnancy category: C

Lactation: Distributed in breast milk; American Academy of Pediatrics classifies scopolamine as compatible with breast-feeding

 

Pregnancy categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

 

Pharmacology of Isopto Hyoscine (scopolamine ophthalmic)

Mechanism of action

Elicits anticholinergic effects at parasympathetic sites in sphincter muscle of the iris and accommodative muscle of the ciliary body; prevents accomodation and dilates pupils