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Definition of X chromosome
Medically reviewed by Min Clinic Staff | Updated: January 2026
X chromosome: The sex chromosome that is found twice in normal females and singly, along with a Y chromosome, in normal males. The complete chromosome complement consists of 46 chromosomes, including the 2 sex chromosomes, and is thus conventionally written as 46,XX for chromosomally normal females and 46,XY for chromosomally normal males.