Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Paraneoplastic pemphigus (PNP)
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Paraneoplastic pemphigus (PNP): a rare, often-fatal, autoimmune disease in which a person’s immune system attacks its own tissues causing painful blistering skin and mucous membranes. Paraneoplastic pemphigus is always associated with an underlying cancerous tumor. In a small number of cases, PNP may go away if the underlying cancer is cured.
Another term for paraneoplastic pemphigus is paraneoplastic autoimmune multiorgan syndrome (PAMS).
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