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Diupres-500: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Diupres-500 - General Information

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Diupres-500 inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. [PubChem]

 

Pharmacology of Diupres-500

Diupres-500 is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Diupres-500 are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

 

Additional information about Diupres-500

Diupres-500 Indication: Foe the treatment of hypertension Mechanism Of Action: Diupres-500's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines. Drug Interactions: Dobutamine Increased arterial pressureDopamine Increased arterial pressureEphedrine Increased arterial pressureEphedra Increased arterial pressureEpinephrine Increased arterial pressureNorepinephrine Increased arterial pressureTerbutaline Increased arterial pressureSalbutamol Increased arterial pressurePseudoephedrine Increased arterial pressureProcaterol Increased arterial pressurePirbuterol Increased arterial pressurePhenylpropanolamine Increased arterial pressurePhenylephrine Increased arterial pressureOrciprenaline Increased arterial pressureMethoxamine Increased arterial pressureMetaraminol Increased arterial pressureMephentermine Increased arterial pressureIsoproterenol Increased arterial pressureFenoterol Increased arterial pressure Food Interactions: Not Available Generic Name: Reserpine Synonyms: Not Available Drug Category: Antipsychotics; Antihypertensive Agents; Peripheral Adrenergic Inhibitors Drug Type: Small Molecule; Approved Other Brand Names containing Reserpine: Cam-Ap-Es; Demi-Regroton; Diupres-250; Diupres-500; Diutensen-R; Dralserp; Hiserpia; Hydrap-ES; Hydromox R; Hydroserpine Plus (R-H-H); Metatensin; Absorption: Not Available Toxicity (Overdose): Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg Protein Binding: 62% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Diupres-500: Tablet Oral Chemical IUPAC Name: Not Available Chemical Formula: C33H40N2O9 Reserpine on Wikipedia: https://en.wikipedia.org/wiki/Reserpine Organisms Affected: Humans and other mammals