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Dermazin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dermazin - General Information

Dermazin is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia]

 

Pharmacology of Dermazin

Dermazin has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Dermazin is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.

 

Additional information about Dermazin

Dermazin Indication: Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Mechanism Of Action: Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Dermazin acts only on the cell membrane and cell wall to produce its bactericidal effect. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Silver sulfadiazine Synonyms: Sulfadiazine silver; SSD; Silver sulfadiazinate; Silver sulphadiazine Drug Category: Antibacterial Agents; Topical Antibiotic; Anti-Infective Agents, Local Drug Type: Small Molecule; Approved Other Brand Names containing Silver sulfadiazine: Silvadene; Thermazene; SSD (1% Silver Sulfadiazine Cream USP); Dermazin; Flamazine; Sildaflo; Absorption: Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue. Toxicity (Overdose): Acute oral toxicity (LD50) in rat is 10001 mg/kg. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Dermazin: Cream Topical Chemical IUPAC Name: silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide Chemical Formula: C10H9AgN4O2S Silver sulfadiazine on Wikipedia: https://en.wikipedia.org/wiki/Silver_sulfadiazine Organisms Affected: Various gram-negative and gram-positive eubacteria; Yeast and other fungi