Chlormerodrine: Full Drug Profile

Chlormerodrine - General Information

Chlormerodrine is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.

Pharmacology of Chlormerodrine

Chlormerodrine is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.

Additional information about Chlormerodrine

Chlormerodrine Indication

Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.

Mechanism Of Action

Chlormerodrine most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na⁺ ion, Cl^- ion and water into the cells, without interfering with the active extrusion of Na⁺ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.

Generic Name

Chlormerodrin

Drug Category

Mercurial Diuretics; Diagnostic aids

Drug Type

Small Molecule; Approved

Other Brand Names containing Chlormerodrin

Chlormerodrine; Chlormeroprin; Chloromeridin; Chloromerodrin; Diurone; Hg-203 chlormerodrin; Katonil; Mercardox; Mercloran; Mercoral; Merculest; Merilid; Neogidrin; Neohydrin; Oricur; Percapyl; Promeran; Promerane;

Toxicity (Overdose)

As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.

Chemical IUPAC Name

[3-(carbamoylamino)-2-methoxypropyl]-chloromercury

Chemical Formula

C5H11ClHgN2O2

Organisms Affected

Humans and other mammals