Chixin: Full Drug Profile
Chixin - General Information
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Chixin has also been administered orally in the treatment of trypanosomiasis.
Pharmacology of Chixin
Chixin is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem. Chixin is also indicated in skin grafting when bacterial contamination may cause graft rejection or donor site infection, especially in hospitals with a history of resistant bacteria.
Chixin for patients
Chixin Interactions
Chixin Contraindications
- Renal function impairment: polyethylene glycols in the base of the topical solution and the soluble dressing may be absorbed through denuded skin and may not be excreted normally, which may lead to increased blood urea nitrogen (BUN), anion gap, and metabolic acidosis.
- Sensitivity to nitrofurazone or other components of the formulation.
Additional information about Chixin
Chixin Indication: For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms. Mechanism Of Action: The exact mechanism of action is unknown. Chixin inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Nitrofurazone Synonyms: NF; NFZ; Nitrofurazan Drug Category: Trypanocidal Agents; Anti-Infective Agents, Local; Anti-Infective Agents, Urinary Drug Type: Small Molecule; Approved Other Brand Names containing Nitrofurazone: Actin-N; Aldomycin; Alfucin; Amifur; Babrocid; Becafurazone; Biofuracina; Biofurea; Chemofuran; Chixin; Cocafurin; Coxistat; Dermofural; Dymazone; Dynazone; Eldezol; Eldezol F-6; Fedacin; Flavazone; Fracine; Furacilin; Furacillin; Furacin; Furacin Soluble Dressing; Furacin Topical Cream; Furacin Topical Solution; Furacin-E; Furacin-HC; Furacine; Furacinetten; Furacoccid; Furacort; Furacycline; Furaderm; Furagent; Furalcyn; Furaldon; Furalone; Furametral; Furan-Ofteno; Furaplast; Furaseptyl; Furaskin; Furatsilin; Furaziline; Furazin; Furazina; Furazol W; Furazone; Furazyme; Furesol; Furfurin; Furosem; Fuvacillin; Hemofuran; Ibiofural; Mammex; Mastofuran; Monafuracin; Monafuracis; Monofuracin; NF-7; NFS; Nefco; Nifucin; Nifurid; Nifuzon; Nitrofural; Nitrofuran; Nitrofurane; Nitrofurol; Nitrozone; Otofural; Otofuran; Sanfuran; Spray-Dermis; Spray-Foral; Vabrocid; Vadrocid; Yatrocin; Absorption: Well absorbed. Toxicity (Overdose): Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated. Protein Binding: Not Available Biotransformation: Nitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules (Polnaszek et al., 1984; Kutcher & McCalla, 1984; McCalla 1979; McCalla et al., 1975). Half Life: 5 hours Dosage Forms of Chixin: Dressing Topical Ointment Topical Powder Oral Powder Topical Powder, for solution Oral Solution Intrauterine Solution Topical Solution Intravenous Tablet Oral Capsule Oral Solution Oral Liquid Intramuscular Chemical IUPAC Name: [(5-nitrofuran-2-yl)methylideneamino]urea Chemical Formula: C6H6N4O4 Nitrofurazone on Wikipedia: https://en.wikipedia.org/wiki/Nitrofurazone Organisms Affected: Gram negative and gram positive bacteria