Celontin: Full Drug Profile

Celontin - General Information

Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia]

Pharmacology of Celontin

Not Available

Additional information about Celontin

Celontin Indication

For the control of absence (petit mal) seizures that are refractory to other drugs.

Mechanism Of Action

Celontin suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.

Generic Name

Methsuximide

Synonyms

Mesuximide; Mesuximidum [inn-latin]; Mesuximida [inn-spanish]; Methsuximid; Metosuccimmide [DCIT]; Metsuccimide; N,2-Dimethyl-2-phenylsuccinimide; N-methyl-alpha-methyl-alpha-phenylsuccinimide; Alpha-methylphensuximide; Alpha-methyl-alpha-phenyl n-methyl succinimide; 1,3-Dimethyl-3-phenylsuccinimide; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion

Drug Category

Anticonvulsants

Drug Type

Small Molecule; Approved

Other Brand Names containing Methsuximide

Petinutin; Celontin;

Toxicity (Overdose)

Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 &

Half Life

1.4-2.6 hours for mesuximide and 28-38 hours for the active metabolite.

Dosage Forms of Celontin

Capsule Oral

Chemical IUPAC Name

1,3-dimethyl-3-phenylpyrrolidine-2,5-dione

Chemical Formula

C12H13NO2

Methsuximide on Wikipedia

https://en.wikipedia.org/wiki/Methsuximide

Organisms Affected

Humans and other mammals