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CAM-AQI: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

CAM-AQI - General Information

A 4-aminoquinoquinoline compound with anti-inflammatory properties.

 

Pharmacology of CAM-AQI

CAM-AQI, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. CAM-AQI is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension. They depress respiration and cause diplopia, dizziness and nausea.

 

CAM-AQI for patients

 

CAM-AQI Interactions

 

CAM-AQI Contraindications

Because amodiaquine may concentrate in the liver, the drug should be used with caution in patients with hepatic disease or alcoholism, and in patients receiving hepatotoxic drugs.

 

Additional information about CAM-AQI

CAM-AQI Indication

For treatment of acute malarial attacks in non-immune subjects.

Mechanism Of Action
The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.
Generic Name
Amodiaquine
Synonyms
Amodiaquin; Amodiaquine USP24; Amodiaquine, ring-closed
Drug Category
Amebicides; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials
Drug Type
Small Molecule; Approved
Other Brand Names containing Amodiaquine
Basoquin; CAM-AQ1; CAM-AQI; Camochin; Camoquin; Camoquin HCL; Camoquinal; Camoquine; Flavoquin; Flavoquine; Miaquin;
Absorption
Rapidly absorbed following oral administration.
Toxicity (Overdose)
LD50 (mouse, intraperitoneal) 225 mg/kg, LD50 (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.
Biotransformation
Hepatic biotransformation to desethylamodiaquine (the principal biologically active metabolite) is the predominant route of amodiaquine clearance with such a considerable first pass effect that very little orally administered amodiaquine escapes untransformed into the systemic circulation.
Half Life
5.2 ± 1.7 (range 0.4 to 5.5) minutes
Chemical IUPAC Name
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
Chemical Formula
C20H22ClN3O
Organisms Affected
Plasmodium