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Ansolysen: Full Drug Profile
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Ansolysen - General Information
A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.
Pharmacology of Ansolysen
Ansolysen acts as a ganglionic blocking agent. Ansolysen inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously.
Additional information about Ansolysen
- Ansolysen Indication
Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
- Mechanism Of Action
- Ansolysen binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
- Generic Name
- Pentolinium
- Synonyms
- Pentolinium tartrate; Pentolonium; Pentolonum
- Drug Category
- Antihypertensive Agents
- Drug Type
- Small Molecule; Approved
- Other Brand Names containing Pentolinium
- Ansolysen;
- Toxicity (Overdose)
- Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.
- Chemical IUPAC Name
- 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
- Chemical Formula
- C15H32N2+2
- Organisms Affected
- Humans and other mammals